Dallas Chiropractors Best Practices

Decrease Inflammation Through Diet

A review of:
Hussain T, Tan B, Yin Y, Blachier F, Tossou MC, Rahu N. Oxidative Stress and Inflammation: What Polyphenols Can Do for Us? Oxid Med Cell Longev. 2016;2016:7432797. doi: 10.1155/2016/7432797. Epub 2016 Sep 22. PMID: 27738491; PMCID: PMC5055983.


Reviewed by Dr. John Wertish

Summarized Review of Conclusions

Polyphenols are compounds with various potential biological properties such as antioxidants, anti-inflammatory, antineoplastic, antiaging, cardioprotective, anticancer, and antimicrobial properties. Polyphenols are gaining interest due to their wide applications in different pathological situations. Oxidative stress activates a variety of inflammatory mediators involved in several chronic diseases. Clinical evidence suggests that oxidative stress and inflammation linked to overproduction of ROS are likely to represent an important component for the development of several diseases including inflammation-associated chronic diseases


Quotes from the article

“Antioxidant properties of the polyphenols may be beneficial in the process of inflammation and in inflammation induced carcinogenesis [60, 61]. Many epidemiological and human studies have proposed that daily intake of polyphenols rich diet such as fruits, vegetables, cocoa, tea, and wine may exhibit fruitful effects in humans [62, 63].”

“The literature revealed that intuitional supplementation of polyphenols decreases the incidences of different forms of cancer [85]. Polyphenols exert protection against gastrointestinal tract cancers whereas variety of polyphenols in fruits and vegetables are responsible for preventing the incidences of colon cancer [86]. Intake of green tea has been suggested to lower the incidences of biliary tract [87], bladder [88], breast [89], and colon cancer, respectively [90].”


Introduction to the Research

Oxidative stress refers to the excessive production of reactive oxygen species (ROS) in the cells and tissues and antioxidant system cannot be able to neutralize them. Imbalance in this protective mechanism can lead to the damage of cellular molecules such as DNA, proteins, and lipids [1]. Reactive oxygen species are normally produced within the body in limited quantity and are important compounds involved in the regulation of processes involving the maintaining of cell homeostasis and functions such as signal transduction, gene expression, and activation of receptors [2]. Mitochondrial oxidative metabolism in cells produces ROS species and organic peroxides in the process of cell respiration [3]. In addition, in hypoxic conditions, nitric oxide may also be produced during the respiratory chain reaction [4]. This latter reactive nitrogen species (RNS) may further lead to the production of reactive species such as reactive aldehydes, malondioaldehyde, and 4-hydroxynonenal [5]. Main targets of oxidative stress are proteins, lipids, and DNA/RNA, and modifications in these molecules may increase the chances of mutagenesis. ROS/RNS overproduction notably over a prolonged period of time can cause damage of the cellular structure and functions and may induce somatic mutations and preneoplastic and neoplastic transformations. Then, excessive production of ROS in cells and tissues may be deleterious if not removed quickly [6]. Indeed, excessive ROS/RNS production may cause irreversible damage to cells resulting in cell death by the necrotic and apoptotic processes [7].

Polyphenols are natural compounds present in plants with numerous biological activities. Phenolic compounds and flavonoids can interact with ROS/RNS and thus terminate chain reaction before cell viability is seriously affected [21].


Research Methodology

This article was a research review of comprehensive evaluation of polyphenols which is found in fruits, vegetables, tea, and other plant-based food. This review aims at exploring the properties of polyphenols in anti-inflammation and oxidation and the mechanisms of polyphenols inhibiting molecular signaling pathways which are activated by oxidative stress, as well as the possible roles of polyphenols in inflammation-mediated chronic disorders.


Research findings:

This research review covered the impact of polyphenols as antioxidants and the impact on our health.  Polyphenols have an impact by reducing free radical damage, inhibit enzymes involved in oxidation, reduce inflammation, cardiovascular disease, neurological disorders, and could be used as an alternative to cancer therapy.


Research References

As always with these reviews, these are my takeaways from the article and I encourage you to read the article in its entirety.  The references used in this article by the authors of this article are listed here.


Our Message

When you are looking for a Chiropractor near you that you can trust, choose one who will not only help you with your back pain, neck pain, or headaches but who will also guide you to living a healthier lifestyle to keep you out of pain. Our East Dallas Chiropractors, located in Lakewood near the corner of Mockingbird Ln. and Abrams Rd., will teach you what the research says about how and why we should eat a better diet, move more and have more positive thoughts. By improving these areas of our lives we can restore motion and decrease stress while staying out of pain!