East Dallas Chiropractor Best Practices

Research Commentary;

Reducing Cold and Flu with Probiotics

A review of

Zhang H, Yeh C, Jin Z, Ding L, Liu BY, Zhang L, Dannelly HK. Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate. Synth Syst Biotechnol. 2018 Mar 12;3(2):113-120. doi: 10.1016/j.synbio.2018.03.001. PMID: 29900424; PMCID: PMC5995450.

By Dr. Erik Waldeland

Reducing Cold and Flu with Probiotics

Summarized Review Conclusions

The human gut microbiota is an important environmental factor for human health with evolutionarily conserved roles in immunity, metabolism, development, and behavior of the host. Probiotic organisms are claimed to offer several functional properties including stimulation of immune system. Results of this study demonstrated that probiotics were safe and effective for fighting the common cold and influenza-like respiratory infections by boosting the immune system.

“The immune system is complex and needs to be maintained and constantly stimulated by antigens in order to recognize and neutralize pathogens efficiently.”

“The findings of our study indicate that the combination of probiotics (Lactobacillus paracasei, Lactobacillus casei 431® and Lactobacillus fermentum PCC®) could reduce the incidence of the upper respiratory infection, which is possible by increasing the level of IFN-γ in the blood and sIgA in the gut.”


Introduction to the Research

The intestinal microbiota is an ecosystem containing tens of trillions of microorganisms including many species of known bacteria. The purpose of this study is to investigate the effects of a probiotic supplementation on adult volunteers who have contracted the common cold four or more times in the past year. This study is a single center, double-blind, randomized, controlled, prospective trial.


Research Methodology

Subjects (136) were screened, randomized and enrolled; 67 subjects completed each group with one dropout per group. Subjects were assigned to the groups randomly by the physician and the intervention began immediately following randomization. During the intervention, all subjects received once daily doses; probiotic drink (150 mL) or placebo drink (150 mL) was administered after lunch for a total of 12 weeks.


Research Findings

The consumption of probiotics significantly reduced the incidence of upper respiratory infection (p < 0.023) and flu-like symptoms with an oral temperature higher than 38 °C (p < 0.034) as compared to the placebo group. Subjects that consumed probiotics demonstrated a significantly higher level of IFN-γ in the serum (p < 0.001) and sIgA in the gut (p < 0.010) as compared to the placebo group and a significant higher level of serum IFN-γ (p < 0.001) and gut sIgA (p < 0.001) as compared to their baseline test results. In contrast, there were no significant differences in the serum IL-4, IL-10, IgA, IgG or IgM between the probiotics and the placebo groups. Results of this study demonstrated that probiotics were safe and effective for fighting the common cold and influenza-like respiratory infections by boosting the immune system.

As always with these reviews, these are my takeaways from the article and I encourage you to read the article in its entirety.  The references used in this article by the authors of this article are listed here.

Our Message

When you are looking for a Chiropractor near you that you can trust, choose one who will not only get rid of your back pain, neck pain, or headaches but who will also guide you to living a healthier lifestyle to keep you out of pain. Our East Dallas Doctors, located in Lakewood at the corner of Mockingbird Ln. and Abrams Rd., are here to teach you that taking care of your mental health and getting the proper nutrients, like Omega 3’s, is just as important as the chiropractic adjustment to stay healthy, lower inflammation and limit pain.